Monday, April 30, 2007

Paediatric Approaches to ALL

We posted earlier about the advantages of paediatric protocols in the treatment of Acute Lymphoblastic Leukaemia in young adults.

There now seems to be evidence that paediatric protocols may be advantageous up to the age of 40 or beyond!

In the French GRAALL-2003 trial a paediatric-type protocol was applied to adults and showed significantly increased rates of 2-year Event Free Survival and Overall Survival in comparison with the earlier LALA-94 trial adult protocol. The results were even more impressive for T-cell lineage ALL.

Link to abstract of presentation at the 2006 American Society of Hematology conference here.

At the same conference the Canadian Princess Margaret Hospital presented evidence that
a modified Dana Farber Cancer Institute pediatric ALL protocol (DFCI 91-01) was beneficial for adults.

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