Just culled from the BBC "Mr Brown is thought likely to carry out the bulk of his Cabinet reshuffle on Thursday, but it has already emerged that one definite change will see Patricia Hewitt stepping down as health secretary."
Thursday update: It is tipped that Alan Johnson, formerly Education Secretary, will be appointed to Health. Patricia is definitely stepping down to spend more time with her elderly parents in Oz (? presumably she'll be resigning as an MP?).